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. 2021 May 25;11(15):7337–7359. doi: 10.7150/thno.57804

Figure 6.

Figure 6

MRPL52 promotes the survival and metastasis of BC cells in vivo. (A) Representative IF images of MRPL52 (red) and pimonidazole (green) in 4T1 xenograft tumors. Yellow color in the merged image represents co-localization of MRPL52 and pimonidazole. (B) Images, (C) growth curves and (D) weights of xenograft tumors (mean ± SD, n = 5). *P < 0.05. Scale bars, 1 cm. (E) TUNEL staining of xenografts (mean ± SD, n = 5). *P < 0.05. Scale bars, 100 µm. H&E analysis of (F) lung and (G) liver metastasis in mice. Scale bars, 100 µm. The relative metastatic regions (tumor area/organ area) were calculated according to H&E analysis (mean ± SD, n = 5). The microscopically visible metastatic nodules on the surface of lung and liver were counted (mean, n = 5). *P < 0.05.