Table 1.

Relationship between circRHOBTB3 expression level and clinicopathological features of CRC patients

Clinicopathological parameters	N = 83	circRHOBTB3 expression		P value
		Low expression (n = 42)	High expression (n = 41)
Gender
Male	52	25	27
Female	31	17	14	0.551
Age
< 60	27	10	17
≥ 60	56	32	24	0.086
Tumor location
Colon	42	22	20
Rectum	41	20	21	0.743
Differentiation
Well and Moderate	59	31	28
Poor	17	7	10	0.833
Clinical stage
I + II	39	14	25
III + IV	44	28	16	0.012
T stage
T1-2	16	4	12
T3-4	67	38	29	0.023
Lymph node metastasis
Absent	43	15	28
Present	40	27	13	0.003
Distant metastasis
Absent	70	33	37
Present	13	9	4	0.144
Nerve Invasion
Absent	72	33	39
Present	10	9	1	0.009
Tumor size
≤ 5 cm	65	29	36
> 5 cm	18	13	5	0.038
CEA level
< 5 µg/mL	49	26	23
≥ 5 µg/mL	34	16	18	0.591
Chronic diarrhea or constipation
Absent	52	25	27
Present	31	17	14	0.551

CEA: carcinoembryonic antigen; P values were calculated using chi-square tests.