Figure 2.
Validation of closed-loop MRgFUS system for applying safely localized transcranial hyperthermia in rodents (A) MR thermometry images (in Celsius) from experiments in healthy mice fused over T2 weighted images showing localized heat deposition using two different MRgFUS systems, with central frequency of 1 MHz and 1.7 MHz, respectively (5 mice per group). The FUS element had the same f-number. The white circle represents the targeted area. (B) Average focal temperature measurement (in Celsius) during transcranial hyperthermia experiment, showing narrower temperature ranges with the 1.7 MHz MRgFUS (SEM: 0.045 - 1.7 MHz vs. 0.084 - 1 MHz). (C, D) H&E and Nissl stained images of harvested brain tissues at 24 hrs (left - untreated, right - treated). Magnified images of 3 different samples are shown. The number of mice used per group was 3.