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Nanoparticle-mediated alleviation of intratumoral hypoxia. A) HIF-1α staining of tumor sections collected 24 h after nanoparticle administration. Scale bars: 50 μm. B) Quantification of median fluorescence intensity of (A). C) Photoacoustic imaging of tumor oxygen levels before and after administration of PLT/CANS. D) Semi-quantitative analysis of (C) using ImageJ. E) Western blots of OPN, HIF-1, and CA9 in tumor tissue from nanoparticle-treated mice.
