Figure 6.
R13 administration ameliorated gastrocnemius cross-sectional area, increased number of spinal cord motor neurons, and decreased astrocytes and microglia numbers in spinal cord of SOD1G93A. (A) The representative graph of gastrocnemius cross-sectional area by H&E staining. (B, E) The representative image of motor neuron in spinal cord by Nissl staining and quantitative analysis. (C, D, F, G) The representative image of positive immunostaining of GFAP (astrocytes) and Iba1 (microglia) in spinal cord and quantitative analysis. Data was expressed as Mean ± SEM. *, p < 0.05 vs. ALS vehicle group; ##, p < 0.01, ####, p < 0.0001 vs. WT group. n = 3 for each group.