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. 2021 May 21;11(15):7130–7143. doi: 10.7150/thno.60582

Figure 1.

Figure 1

Trial design and imaging workflow. (A) Panitumumab-IRDye800CW was infused in patients with contrast enhancing high-grade gliomas prior to surgery. (B) Intraoperative near-infrared imaging of the surgical field with neuronavigation (open field) and resected tissue (closed field). OR: operating room. (C) Microscopic and macroscopic NIR fluorescence imaging of fixed tissue and corresponding histopathological stainings post surgery. Red arrows: tissue imaging path; gray arrows: tissue processing path. NIR fluorescence imaging instruments (vendors): ① SPY-PHI (Novadaq); ② IGP-ELVIS (Li-COR Biosciences); ③ Pearl Trilogy (Li-COR Biosciences); ④ Odyssey CLx (Li-COR Biosciences). Images reproduced with permission from Medtronic, Stryker, and LI-COR, Inc.