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. 2021 Jun 15;218(7):e20201541. doi: 10.1084/jem.20201541

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© 2021 Caiado et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 1. — Causes and consequences of inflammation on HSC functionality. Schematic representation of current understanding in the field on the major causes of systemic inflammation known to impact HSC biology in mouse models (infection, microbiota, carcinogens, inflammatory diseases, aging). Each cause in distributed in a gradient regarding the duration of inflammation: acute to chronic. HSC properties during homeostatic responses (more frequently associated with acute inflammation) or functional decline (more frequently associated with chronic inflammation) are depicted.