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. 2021 Jun 15;218(7):e20201541. doi: 10.1084/jem.20201541

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© 2021 Caiado et al.

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Figure 2. — Effects of acute and chronic inflammatory signaling in HSC biology. Schematic representation of the antagonizing effects of acute or chronic in vivo cytokine exposure on murine HSC functions. Here, acute is defined has exposure of the indicated cytokine in one to three consecutive single daily doses, while chronic represents more than three consecutive daily exposures (in agreement with classic definitions in the field). The left panel depicts HSCs in homeostatic state and the published expression levels of cytokine receptors. Acute and chronic exposures panels depict the pathways and the respective cellular effects of the exposure to the indicated cytokines. The bottom scheme shows loss of HSC functionality from homeostasis to acute to chronic inflammatory exposure. 2ary, secondary.