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Schematic indicating conformational bias of SERT Ala56 and Asn605 relative to WT SERT. Limited proteolysis, fluorescence resonance energy transfer (FRET), and cysteine-accessibility studies indicate that the Ala56 and Asn605 coding variants impose conformation that leading to a more outward-facing conformation of the transporter, facilitating access of 5-HT to the substrate-binding site under resting conditions. Modified from Quinlan et al. (2019).
