Figure 4.

Pharmacological p38α MAPK inhibitor administration normalizes in vivo hippocampal 5-HT clearance rates in SERT Ala56 mice. (A) SERT Ala56 mice exhibit an elevated rate of hippocampal 5-HT clearance as compared to their SERT Gly56 counterparts when assessed by high-speed in vivo chronoamperometry. (B) Increased 5-HT clearance rate of SERT Ala56 mice is normalized to WT rates by repeated p38α MAPK inhibition with MW150 (5 mg/kg, QD, i.p. × 7 days). Figure adapted from Robson et al. (2018).