Table 2.

Histopathologic features of 20 primary esophageal melanomas

Case	Cell type	Pigment	Atypia	Mitoses/10 HPF	Tumor necrosis	Junctional activity	Pagetoid spread	Ulceration
1	Epithelioid to spindle	No	Moderate	11	Yes	Yes	No	Yes
2	Epithelioid	No	Moderate	10	No	Yes	No	Yes
3	Epithelioid	Yes	Moderate	0	No	Yes	No	Yes
4	Epithelioid	Yes	Moderate (focally severe)	15	No	Yes	No	Yes
5*	Epithelioid	Yes	Moderate	6	No	Yes	No	Yes
6	Epithelioid	Yes	Moderate	6	No	Yes	Yes (f)	Yes
7	Epithelioid	Yes	Moderate (focally severe)	14	Yes	Yes	No	Yes
8*	Epithelioid	Yes	Moderate	4	No	Yes	No	No
9	Epithelioid	Yes	Moderate	4	No	Yes	No	Yes
10	Epithelioid	Yes	Moderate	23	No	Yes	Yes	Yes
11§	Epithelioid	Yes	Moderate	n/a	n/a	Yes	n/a	n/a
12	Epithelioid to round cell	Yes	Moderate	31	No	Yes	Yes	Yes
13	Epithelioid to spindle	Yes	Moderate	19	Yes	Yes	No	Yes
14	Epithelioid	Yes	Moderate (focally severe)	9	No	Yes	No	Yes
15	Epithelioid	Yes	Moderate	2	No	Yes	No	Yes
16	Epithelioid	Yes	Moderate	11	Yes	Yes	Yes	Yes
17	Spindle to epithelioid	Yes	Severe	14	No	Yes	No	Yes
18	Epithelioid	No	Moderate (focally severe)	7	No	Yes	Yes (f)	Yes
19	Epithelioid	Yes	Moderate	12	No	Yes	Yes (f)	No
20	Epithelioid	Yes	Moderate	29	No	Yes	No	Yes

HPF high-power fields, f focal, n/a = not available

^§diagnostic biopsy

^*some data previously reported [27, 28]