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. 2021 Jun 3;12:652901. doi: 10.3389/fgene.2021.652901

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Copyright © 2021 Pang, Luo, Wei, Cao, Qi, Song, Liu, Li, Zhang, Li, Chen, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional analysis of the genes regulated in both silicosis and IPF. (A) Statistics of the gene counts regulated in both silicosis and IPF. Pink squares indicate genes regulated in the same direction (up or down) in both diseases; blue squares indicate genes regulated in different directions in the two diseases. (B) The top 10 pathways significantly enriched for the 500 genes up-regulated in both silicosis and IPF. (C) The top 10 significant biological processes enriched for the 500 genes up-regulated in both silicosis and IPF. The size of dots reflects the gene counts for each process. Dot color reflects adjusted p-values, where the most significant result is red. (D) Representative genes selected from significant pathways shared by silicosis and IPF.