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. Author manuscript; available in PMC: 2021 Jul 3.
Published in final edited form as: Circ Res. 2020 Mar 31;127(2):207–224. doi: 10.1161/CIRCRESAHA.119.316155

Figure 1. Graphical abstract.

Figure 1.

a) Cross sectional view of the design template for the human chambered cardiac pump (hChaMP). The template was derived from an MRI scan of the human heart that was reduced in scale 10 times (1.3 cm at its longest axis, akin to the size of a murine heart) and modified to harbor a one way flow loop through the chambers of the heart template. The goal was to create a geometrically complex cardiac tissue with contiguous muscle and associated pump function. b) The panels designate the unique organoid-like approach to generate the hChaMP wherein human induced pluripotent cells (hiPSCs) were deposited with an optimized, ECM-based bioink that allowed for expansion of the hiPSCs to attain tissue-like densities and subsequent differentiation to cardiomyocytes. Over time, the hChaMP could beat synchronously, build pressure and move fluid akin to a living pump.