Table 1.
Retrospective cohort studies that analysed the efficacy of radiotherapy treatment and the occurrence of post-exposure complications (including RION) in head and neck tumours
| Author/Year | Study period | Location and type of tumour | Total number of patients in the study | Mean prescribed dose/fractions | Number of occurrences of RION | Study follow- up period |
|---|---|---|---|---|---|---|
| Wang et al., 201739 | 2008–2014 | Cavernous sinus haemangioma | 31 | 21 to 22 Gy in 3 to 4 fractions | 0 | 30 months |
| Astradsson et al., 201740 | 1999–2015 | Craniopharyngioma | 60 | 54 Gy (1.8 or 2 Gy per fraction) | 1 | 22 years |
| Astradsson et al., 201441 | 1999–2009 | Meningioma of base of skull | 39 | 54 Gy (1.8 or 2 Gy per fraction) | 4 | 2 years (minimum) |
| Astradsson et al., 201441 | 1999–2009 | Pituitary adenoma | 55 | 54 Gy (1.8 or 2 Gy per fraction) | 7 | 2 years (minimum) |
| Kim et al., 201342 | 1998–2007 | Pituitary adenoma | 76 | 50.4 Gy (28 fractions) | 0 | Mean 6.8 years |
| Somani et al., 200943 | 1998–2006 | Choroidal melanoma | 64 | 70 Gy (5 fractions) | 33 | 26 months |
| Elhateer et al., 200844 | 2000–2005 | Pituitary macroadenoma | 13 | 50.4 Gy (1.8 per fraction) | 0 | Mean 24 months |
| Selch et al., 200445 | 1997–2002 | Cavernous sinus meningioma | 45 | 50.4 Gy (1.8 per fraction) | 0 | 3 years |