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Model of how CL/P arises in A/WySN embryos. Wnt9bIAP (Clf1) methylation levels and Wnt9b gene expression levels constitute a liability factor (A, B), whose loss has a nonlinear relationship to morphology (shape) (C), with an accompanying increase in phenotypic variance in the steep region of the curve. The increased variance is also associated with cleft penetrance
