Table 2.
Gene Ontology Classifications for Differentially Abundant Proteins
| abundance | category | term | count | % | FDR |
|---|---|---|---|---|---|
| up | BP | cell adhesion | 26 | 6.6 | 4.46 × 10−2 |
| up | BP | extracellular matrix organization | 22 | 5.6 | 4.46 × 10−6 |
| up | BP | cell migration | 15 | 3.8 | 4.22 × 10−2 |
| up | BP | interferon-γ-mediated signaling | 10 | 2.5 | 3.86 × 10−2 |
| up | CC | extracellular exosome | 142 | 36.0 | 4.37 × 10−22 |
| up | CC | plasma membrane | 134 | 34.1 | 5.39 × 10−5 |
| up | CC | extracellular space | 70 | 17.8 | 5.36 × 10−9 |
| up | CC | focal adhesion | 50 | 12.7 | 5.15 × 10−21 |
| up | CC | Cell surface | 47 | 11.9 | 9.10 × 10−13 |
| up | CC | Cell–cell junction | 21 | 5.3 | 2.52 × 10−2 |
| up | CC | extracellular matrix | 20 | 5.1 | 2.47 × 10−2 |
| up | CC | actin cytoskeleton | 19 | 4.8 | 1.24 × 10−3 |
| up | CC | membrane raft | 16 | 4.1 | 4.48 × 10−2 |
| down | BP | Cell division | 39 | 20.9 | 7.07 × 10−25 |
| down | BP | DNA replication | 31 | 16.7 | 1.09 × 10−26 |
| down | BP | DNA repair | 23 | 12.4 | 6.41 × 10−12 |
| down | BP | Cell proliferation | 17 | 9.1 | 2.18 × 10−3 |
| down | BP | DNA replication initiation | 15 | 8.1 | 6.14 × 10−17 |
| down | CC | nucleus | 118 | 63.4 | 4.65 × 10−20 |
| down | CC | Cytoplasm | 78 | 41.9 | 3.38 × 10−2 |
| down | CC | nuclear chromatin | 14 | 7.5 | 7.70 × 10−5 |
| down | MF | protein binding | 133 | 71.5 | 2.30 × 10−8 |
| down | MF | DNA binding | 41 | 22.0 | 2.97 × 10−4 |
| down | MF | ATP binding | 37 | 19.9 | 1.16 × 10−3 |
| down | MF | Chromatin binding | 23 | 12.4 | 1.09 × 10−7 |
a
Threshold for including a given GO category: >10 proteins per category and a false discovery rate (FDR) ≤ 0.05. BP, biological pathway; CC, cellular component; MF, molecular function.