Table 3.
KEGG Pathway Classifications for Differentially Abundant Proteins
| abundance | category | pathway | count | % | FDR |
|---|---|---|---|---|---|
| up | hsa04512 | ECM–receptor interaction | 11 | 13.6 | 1.60 × 10−4 |
| up | hsa04979 | cholesterol metabolism | 5 | 10.4 | 3.63 × 10−2 |
| up | hsa05410 | hypertrophic cardiomyopathy | 8 | 10.1 | 6.10 × 10−3 |
| up | hsa00830 | retinol metabolism | 6 | 10.0 | 2.49 × 10−2 |
| down | hsa03030 | DNA replication | 16 | 44.4 | 9.75 × 10−19 |
| down | hsa03430 | mismatch repair | 5 | 21.7 | 1.20 × 10−4 |
| down | hsa03410 | base excision repair | 5 | 15.2 | 4.80 × 10−4 |
| down | hsa04110 | cell cycle | 16 | 13.0 | 9.05 × 10−12 |
| down | hsa00240 | pyrimidine metabolism | 11 | 11.0 | 2.20 × 10−7 |
| down | hsa03420 | nucleotide excision repair | 5 | 10.9 | 1.80 × 10−3 |
| down | hsa03440 | homologous recombination | 4 | 10.0 | 8.50 × 10−3 |
a
Threshold for including a given KEGG pathway category: Number of proteins were ≥10% of the background gene count per category and a false discovery rate (FDR) ≤ 0.05.