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. 2021 Jun 16;9(6):e001514. doi: 10.1136/jitc-2020-001514

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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CAR.CD19 T-cells are able to control in vivo expansion of CAR positive lymphoma in a xenograft mouse model. (A) Schematic representation of the experimental design, with CAR.CD19_SL/LH positive/FF-Luciferase positive Daudi cells, infused at day−3. At day 0, mice were evaluated for lymphoma engraftment and treated with 10×10⁶ untransduced (NT) or CAR.CD19_SL/LH T-cells/mouse. (B) Bioluminescence imaging of each treated mouse. (C) Mean±SD of bioluminescence values of the two mice cohorts, receiving NT (black line) or CAR.CD19_SL/LH T-cells (gray line). *p≤0.05. CAR, chimeric antigen receptor; FF, firefly; NT, non-transduced.