Table 2. Nonsynonymous SNPs at insecticide target sites genes associated with kdr, recovered, or dead Aedes aegypti exposed to permethrin.
Gene identification, chromosome (Ch), SNP site and amino acid residue (based in the AaegL5 genome assembly), LOD = -log10(p value vector base gene identification (from www.vectorbase.org). Voltage-gated calcium channel (VGCC), voltage-gated sodium channel (VGSC), gamma-aminobutyric acid type B receptor subunit 2 (GPRGBB3), acetylcholinesterase/hydrolase (ACE), and G protein-activated inward rectifier potassium channel 3 (KCNJ3).
| Gene | Gene ID | Ch | Site | Residue | LOD | Vector Base ID |
|---|---|---|---|---|---|---|
| kdr vs recovered | ||||||
| VGSC | LOC5567355 | 3 | 316014588 | S679T | 13.74 | AAEL006019 |
| 316080722 | V410L | 12.25 | ||||
| GPRGBB3 | LOC5569525 | 2 | 470687501 | G18V | 8.38 | AAEL007709 |
| 470687506 | T20P | 5.50 | ||||
| ACE | LOC5570776 | 3 | 29508519 | L113S | 5.29 | AAEL008532 |
| 29508507 | Q117P | 4.22 | ||||
| KCNJ3 | LOC5571228 | 3 | 50262691 | S471N | 3.69 | AAEL013373 |
| 50262715 | G479V | 3.28 | ||||
| Recovered vs dead | ||||||
| VGCC | LOC5564339 | 3 | 116602456 | P1661S | 10.92 | AAEL004201 |
| GPRGBB3 | LOC5569525 | 2 | 470687501 | G18V | 7.62 | AAEL007709 |
| 470687506 | T20P | 7.13 | ||||
| acetylcholine receptor | LOC5575838 | 1 | 44469 | K297I | 6.76 | AAEL012106 |
| VGSC | LOC5567355 | 3 | 316080722 | V408L | 4.62 | AAEL006019 |
| 316014588 | S679T | 3.88 | ||||
| Kdr vs dead | ||||||
| VGSC | LOC5567355 | 3 | 316014588 | S679T | 26.11 | AAEL006019 |
| 316080722 | V410L | 25.73 | ||||
| GPRGBB3 | LOC5569525 | 2 | 470713597 | D963G | 5.30 | AAEL007709 |
| 470713596 | S963G | 5.14 | ||||
| ACE | LOC5570776 | 3 | 29508519 | L113S | 5.29 |