Table 3. Nonsynonymous SNPs in cuticular protein genes associated with kdr, recovered, or dead Aedes aegypti exposed to permethrin.
Gene identification, chromosome (Ch), SNP site, amino acid residue (based in the AaegL5 genome assembly), LOD = -log10(p value) and vector base identification (www.vectorbase.org).
| Gene | Gene ID | Ch | Site | Residue | LOD | Vector Base ID |
|---|---|---|---|---|---|---|
| kdr vs recovered | ||||||
| cuticle protein CP14.6 | LOC5577605 | 2 | 366556230 | T7A | 6.46 | AAEL003274 |
| cuticle protein | LOC5572415 | 1 | 276097952 | I229V | 6.02 | AAEL009783 |
| 276097955 | L228I | 5.54 | ||||
| cuticle protein 8 | LOC5565392 | 2 | 288617520 | I170V | 5.89 | AAEL004749 |
| adult cuticle protein 1 | LOC5573913 | 2 | 429075334 | A75T | 5.70 | AAEL002191 |
| cuticle protein CP14.6 | LOC5570386 | 2 | 67628247 | I34V | 5.30 | AAEL008284 |
| cuticle protein 19 | LOC5571330 | 2 | 178019830 | D59N | 3.97 | AAEL008984 |
| larval cuticle protein A2B | LOC5573609 | 3 | 177543253 | S55R | 3.69 | AAEL002099 |
| Recovered vs dead | ||||||
| larval cuticle protein A2B | LOC5577372 | 3 | 186525449 | Q84E | 8.88 | AAEL000419 |
| 186525538 | Y54C | 6.30 | ||||
| 186525518 | S61A | 5.11 | ||||
| endocuticle SgAbd-6 | LOC5570308 | 3 | 6190598 | T112S | 5.82 | AAEL008251 |
| cuticle protein | LOC5572416 | 1 | 276091198 | I122V | 5.58 | AAEL009791 |
| 276091186 | A126T | 3.91 | ||||
| endocuticle SgAbd-5 | LOC5568889 | 2 | 318779482 | A14V | 5.57 | AAEL007194 |
| cuticle protein 19 | LOC5571355 | 2 | 178378901 | A14V | 4.10 | AAEL008979 |
| larval cuticle protein LCP-30 | LOC5577596 | 2 | 366431631 | K223N | 4.00 | AAEL003266 |
| cuticle protein 19 | LOC5571330 | 2 | 178019830 | D59N | 3.97 | AAEL008984 |
| cuticle protein 6 | LOC5572360 | 3 | 284327757 | P95A | 3.85 | AAEL009752 |
| flexible cuticle protein 12 | LOC110679003 | 3 | 127977229 | G49S | 3.45 | AAEL002458 |
| kdr vs dead | ||||||
| adult cuticle protein 1 | LOC5573913 | 2 | 429075334 | A75T | 6.58 | AAEL002191 |
| endocuticle SgAbd-6 | LOC5570308 | 3 | 6190636 | H99R | 5.85 | AAEL008251 |
| cuticle protein CP14.6 | LOC5575766 | 2 | 14463512 | I16V | 5.23 | AAEL002725 |
| pupal cuticle protein 36a | LOC5565726 | 3 | 218238646 | P304A | 5.09 | AAEL004951 |
| larval cuticle protein A2B | LOC5577372 | 3 | 186525449 | Q84E | 4.93 | AAEL000419 |
| 186525538 | Y54C | 4.93 | ||||
| pupal cuticle protein 36 | LOC5577597 | 2 | 366494266 | A195T | 4.70 | AAEL003241 |
| cuticle protein CP14.6 | LOC5577605 | 2 | 366556230 | T7A | 4.69 | AAEL003274 |
| cuticle protein 8 | LOC5565392 | 2 | 288617520 | I170V | 4.56 | AAEL004749 |
| larval cuticle protein A2B | LOC5565377 | 2 | 288426029 | Q23* | 4.44 | AAEL004752 |
| larval cuticle protein A2B | LOC5565357 | 2 | 288342641 | A150T | 4.31 | AAEL004760 |
| larval cuticle protein A2B | LOC5565394 | 2 | 288444286 | E32Q | 4.04 | AAEL004772 |
| larval cuticle protein LCP-30 | LOC5577603 | 2 | 366503144 | N33K | 3.77 | AAEL003222 |