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. 2021 Jun 17;17(6):e1009606. doi: 10.1371/journal.pgen.1009606

Table 4. Nonsynonymous SNPs in detoxification genes associated with kdr, recovered, or dead Aedes aegypti exposed to permethrin.

The gene identification, site, amino acid residue (based in the AaegL5 genome assembly), frequency of alternative nucleotide for each phenotype, the associated LOD values, chromosome (Ch) and vector base identification (www.vectorbase.org) are shown. * indicates SNPs occurring in two or more pairwise comparisons.

Gene   Gene ID Site Residue Frequency LOD Ch Vector Base ID
kdr vs recovered         kdr recovered      
CYP4AR2 LOC5572942 380180400 I340V 0.05 0.42 9.44 2 AAEL010154
CYP6AL3 LOC5580020 60675944 V121I 0.67 0.28 7.58 1 AAEL009656
GSTD3 LOC5568347 301213992 A84V 0.83 0.47 7.28 1 AAEL001059
CYP6N15 LOC5571533 419194639 S409G 0.69 0.36 5.39 2 AAEL009122
419194649 L412R 0.65 0.38 3.93
CYP6AG4 LOC110679554 171318386 P138S 0.42 0.13 5.30 3 AAEL007010
CYP325U1 LOC23687635 112553718 K465R 0.63 0.90 5.28 3 AAEL017215
* 112553724 I467T 0.61 0.89 5.23
112553723 T467S 0.17 0.01 3.81
112545541 H82Q 0.02 0.17 3.39
112545315 S7L 0.20 0.43 3.37
112545312 I6T 0.22 0.46 3.64
aldo-keto-red LOC5565864 337751096 M147L 0.62 0.31 5.21 2 AAEL015002
CYP4C51 LOC5569917 74411398 Y230C 0.82 1.00 5.18 1 AAEL008018
CYP9M11 LOC5571540 419111820 K340T 0.27 0.05 4.97 2 AAEL009127
CCEunk7O LOC5571034 326023789 N522S 0.93 0.70 4.80 3 AAEL008757
326024693 S260L 0.93 0.74 3.33
CYP9M8 LOC5572180 357797466 L256M 0.17 0.00 4.69 2 AAEL009591
HPX8A LOC5564683 235832475 L249M 0.20 0.48 4.56 1 AAEL004388
CCEAE3O LOC5575613 190567112 T92A 0.99 0.80 4.50 2 AAEL011944
GSTE1 LOC5569844 351609764 Q84R 0.66 0.90 4.50 2 AAEL007954
CYP9J32 * LOC5571141 240838981 I120V 0.62 0.33 4.43 2 AAEL008846
CYP-6A1 LOC23687976 419270865 G164E 0.00 0.15 4.32 2 AAEL017556
419270849 N159Y 0.00 0.14 3.85
GPXH2 LOC5570587 93505779 P162R 0.00 0.15 4.30 1 AAEL008397
ald-ox 6157 LOC5567568 125411491 N619S 0.21 0.02 4.27 1 AAEL006157
CCEBE1O LOC5576941 42184652 G296E 0.22 0.03 4.26 3 AAEL012886
42184685 V285A 0.25 0.06 3.69
CYP-9f2 LOC23687786 368590144 F471L 0.62 0.87 4.23 3 AAEL017366
CYP6N6 LOC5571528 419242425 V425M 0.44 0.18 4.20 2 AAEL009126
CCEjhe2O * LOC5564561 388003742 M379I 1.00 0.85 4.14 2 AAEL004323
CYP12F5 LOC5573117 423973803 E51D 0.13 0.37 4.09 2 AAEL001960
GSTD2 LOC5568354 299827836 E110K 0.18 0.44 3.99 1 AAEL001078
CYP6AK1 LOC5565728 323189550 L491F 0.06 0.26 3.91 3 AAEL004941
ald-ox 10380 LOC5573274 182632620 I76M 0.20 0.03 3.88 2 AAEL010380
CYP325R1 * LOC5567056 114802440 V4L 0.43 0.19 3.85 3 AAEL005775
CYP6AG6 LOC5568652 171433917 K233N 0.56 0.30 3.79 3 AAEL006992
CYP6AG8 LOC5579193 85685653 S499L 0.80 0.56 3.63 3 AAEL015654
CCEglt1G LOC5567205 334528425 R30Q 0.72 0.47 3.47 3 AAEL000889
GPXH3 * LOC5578481 160895203 C93Y 0.44 0.68 3.30 3 AAEL000495
Recovered vs dead recovered dead
CYP6P12v2 LOC5576391 271406155 R247K 0.63 0.93 6.66 1 AAEL014891
271405591 P416A 0.20 0.52 5.60
271406845 A17G 0.65 0.91 4.98
CYP6CC1 LOC5565579 271421425 I179V 0.52 0.85 6.42 1 AAEL014890
271421451 I170K 0.45 0.14 5.78
271420954 N336Y 0.67 0.92 5.12
271421023 A313T 0.63 0.90 5.06
271421665 Q99E 0.57 0.82 4.04
CYP6M6 LOC5571537 419156371 E407K 0.36 0.72 6.34 2 AAEL009128
CYP325U1 LOC23687635 112553696 M458L 0.93 0.66 5.92 3 AAEL017215
* 112553724 I467T 0.89 0.59 5.74
GPXH3 * LOC5578481 160895203 Y93C 0.68 0.34 5.72 3 AAEL000495
CYP-6A1 LOC23687976 419271436 M354I 0.06 0.31 4.96 2 AAEL017556
419271427 M351I 0.05 0.28 4.67 2
CCEglt2G LOC5567206 334516359 C6F 0.89 0.62 4.77 3 AAEL000862
334516356 A7V 0.88 0.64 4.04
gst-1 LOC5568383 241679156 S68F 0.57 0.29 4.26 3
241679189 I57T 0.44 0.71 3.76
241679148 P71S 0.55 0.29 3.64
CYP325R1 * LOC5567056 114802440 V4L 0.19 0.45 4.24 3 AAEL005775
CYP6AG7 LOC5568653 171418687 F239L 0.34 0.48 4.16 3 AAEL006989
CCEjhe2O * LOC5564561 388003742 M379I 0.85 1.00 4.14 2 AAEL004323
CYP6S3 LOC5571531 419219864 Y347N 0.24 0.51 3.98 2 AAEL009120
419220227 A226S 0.24 0.05 3.92 2
CYP9J15 LOC5579926 368428360 T4I 0.22 0.04 3.96 3 AAEL006795
CYP302A1 LOC5574850 37194734 L162F 0.06 0.26 3.96 2 AAEL015655
aldo-keto-red LOC5571546 418787288 L87V 0.25 0.06 3.85 2
CYP9J32 * LOC5571141 240838981 I120V 0.33 0.60 3.84 2 AAEL008846
CYP12F6 LOC5573113 423984371 S128N 0.18 0.02 3.82 2 AAEL002005
423984353 E122G 0.18 0.02 3.81
CYP4D24 LOC5569665 152855310 N296D 0.76 0.51 3.82 3 AAEL007815
ald-ox 10382 LOC5573295 182981518 A353S 0.66 0.88 3.81 2 AAEL010382
CYP9J20v2 LOC5564757 368529951 S43G 0.51 0.76 3.76 3
CYP9J19 LOC5579933 368517592 A56V 0.22 0.04 3.50 3 AAEL006810
CYP325M3 LOC5576781 111696906 E292D 0.13 0.00 3.30 3 AAEL012765
kdr vs dead kdr dead
CCEunk7O LOC5571034 326025231 A81T 0.44 0.09 7.99 3 AAEL008757
CYP6CC1 LOC5565579 271421665 Q99E 0.45 0.82 7.20 1 AAEL014890
271421425 I179V 0.50 0.85 7.19
271421536 A142T 0.58 0.21 6.98
271421451 I170K 0.46 0.14 6.22
HPX8C LOC5564684 235812974 I87V 0.65 0.27 7.02 1 AAEL004386
CCEglt4H LOC5567220 332923424 N505S 0.92 0.61 6.55 3 AAEL000898
332923434 S502A 0.92 0.65 5.55
GSTD3 LOC5568347 301213992 A84V 0.83 0.49 6.52 1 AAEL001059
CYP6N6 LOC5571528 419242714 E347D 0.40 0.10 6.19 2 AAEL009126
419242211 R496Q 0.59 0.29 4.88
CYP6BB2 LOC5565578 271330273 S15T 0.44 0.78 5.91 1 AAEL014893
CYP6P12v2 LOC5576391 271406845 A17G 0.62 0.91 5.79 1 AAEL014891
CYP-9f2 LOC23687786 368589360 R210Q 1.00 0.80 5.73 3 AAEL017366
368589389 E220K 0.98 0.77 5.32
368589361 H210Q 1.00 0.82 5.10
368589364 D211E 1.00 0.83 4.77
368589380 N217H 0.97 0.76 4.71
368589376 I215M 0.97 0.77 4.64
368589382 Q217H 0.98 0.80 4.39
368589377 H216Y 0.97 0.78 4.32
368589375 K215M 0.97 0.78 4.22
368589352 L207F 1.00 0.85 4.18
368589374 L215M 0.96 0.78 4.15
368589351 S207F 1.00 0.86 4.02
368589378 C216Y 0.97 0.80 3.83
368589348 S206C 1.00 0.87 3.81
368589381 R217H 0.97 0.80 3.72
CYP4J13 LOC5565336 57986853 A269V 1.00 1.00 5.26 2 AAEL013555
aldo-keto red LOC5564116 401732340 Q200K 0.91 0.65 5.19 3 AAEL004095
CYP9J20v2 LOC5564757 368529951 S43G 0.45 0.76 5.16 3
CYP6N13 LOC5571524 419218265 G280D 0.28 0.05 5.15 2 AAEL009137
419217654 T466S 0.54 0.25 4.51
419217648 S468T 0.25 0.54 4.46
HPX8B LOC5564679 235801599 R334H 0.61 0.29 5.15 1 AAEL004390
CYP6N15 LOC5571533 419193410 I17V 0.09 0.34 4.84 2 AAEL009122
aldo-keto red LOC5564116 401732334 L202M 0.09 0.33 4.64 3 AAEL004095
401732336 L201H 0.09 0.33 4.62
HPX6 LOC5575607 271581636 I103M 0.60 0.88 4.55 1 AAEL011941
CYP4D24 LOC5569665 152861353 I13V 0.22 0.03 4.52 3 AAEL007815
CYP9M10 LOC5571539 419123623 V43A 0.30 0.59 4.41 2 AAEL009125
CCEglt2G LOC5567206 334515295 L341* 0.50 0.22 4.36 3 AAEL000862
CYP325S3 LOC5575186 112638606 A10V 0.20 0.02 4.35 3 AAEL000357
CYP9J15 LOC5579926 368428360 T4I 0.23 0.04 4.29 3 AAEL006795
CYP305A6 LOC5573423 119675669 Y331H 0.48 0.75 4.13 2 AAEL002071
CYP12F5 LOC5573117 423973803 E51D 0.13 0.37 4.04 2 AAEL001960
HPX8B LOC5564679 235800898 H118Q 0.13 0.36 4.02 1 AAEL004390
235800944 Y134H 0.55 0.29 3.73
CYP6N17 LOC5572939 380786471 V14L 0.12 0.38 3.94 2 AAEL010158
HPX7 LOC5564694 235765472 V555I 0.10 0.31 3.88 1 AAEL004401
CYP325G2 LOC5576783 111737982 Y434F 0.32 0.10 3.87 3 AAEL012766
CYP6N12 LOC5571529 419234743 K59R 0.48 0.22 3.87 2 AAEL009124
CYP9J10 LOC5564750 368504032 V508L 0.16 0.42 3.79 3 AAEL006798
aldo-keto red LOC5565864 337751096 M147L 0.62 0.36 3.74 2 AAEL015002
337751096 M147L 0.62 0.36 3.74
CYP325V1 LOC23687556 112534260 V495A 0.71 0.92 3.71 3 AAEL017136