Skip to main content
. 2021 Jun 17;16(6):e0250096. doi: 10.1371/journal.pone.0250096

Table 1. Characteristics of trials included in the analysis.

Citation Type of Intervention and Dose Sample Size Age Year Weight Kg Gender(M/F) Surgery Type Citation numbers
ADVANCE-1 Apixaban 2.5mg, bid, 10–14 days 1599 65.9 86.7 1212/1983 TKA 8
Enoxaprin 30mg bid, 10–14 days 1596 65.7 86.7
ADVANCE-2 Apixaban 2.5mg, bid, 10–14 days 1528 67 78 841/2216 TKA 7
Enoxaprin 40mg od, 10–14 days 1529 67 78
ADVANCE-3 Apixaban 2.5mg, bid, 28–35 days 2708 60.9 79.9 2526/2881 THA 6
Enoxaprin 40mg od, 28–35 days 2699 60.6 79.5
APROPOS Apixaban 2.5mg, bid, 10–14 days 153 67.6 82.3 109/198 TKA 9
Enoxaprin 30mg bid, 10–14 days 152 66.5 83.1
RE-MODEL Dabigatran 150, 220mg od, 6–10 days 1382 67.5 82.5 706/1370 TKA 23
Enoxaparin 40mg od, 6–10 days 694 68 82
RE-NOVATE Dabigatran 150, 220mg od, 28–35 days 2309 64 79 1509/1954 THA 24
Enoxaparin 40mg od, 28–35 days 1154 64 78
RE-MOBILIZE Dabigatran 150, 220mg od, 12–15 days 1728 66.1 88 1099/1497 TKA 25
Enoxaparin 30mg bd, 12–15 days 868 66.3 88
RE-NOVATEII Dabigatran 220mg od, 28–35 days 1010 61.9 NR 1042/971 THA 22
Enoxaparin 40mg od, 28–35 days 1003 62
NCT00246025 Dabigatran 150, 220mg od, 6–10 days 255 71.8 NR 319/60 TKA
Placebo 124 71.3
BISTRO-II Dabigatran 150, 300mg od until venography 775 66.2 79 428/739 THA & TKA 21
Enoxaparin 40mg od,until venography 392 65 79
RECORD 1 Rivaroxaban 10mg od, 31–39 days 2209 63.1 78.1 1971/2462 THA 12
Enoxaparin 40mg od, 31–39 days 2224 63.3 78.3
RECORD 2 Rivaroxaban 10mg od, 31–39 days 1228 61.4 74.3 1139/1318 THA 13
Enoxaparin 40mg od, 10–14 days 1229 61.6 75.2
RECORD 3 Rivaroxaban 10mg od, 10–14 days 1220 67.6 80.1 781/1678 TKA 14
Enoxaparin 40mg od, 10–14 days 1239 67.6 81.2
RECORD 4 Rivaroxaban 10mg od, 11–15 days 1526 64.4 84.7 1060/1974 TKA 15
Enoxaparin 30mg bid, 11–15 days 1508 64.7 84.4
PROOF CONCEPT Rivaroxaban 5, 10mg bid, 5–9 days 148 66.2 77.3 127/183 THA
Enoxaparin 40mg od, 5–9 days 162 64 79
ODIXA KNEE Rivaroxaban 10mg od, 5–9 days 103 67 86.4 84/123 TKA 17
Enoxaparin 30mg bid, 5–9 days 104 66 89.3
ODIXA HIP od Rivaroxaban 10mg od, 5–9 days 142 64 75.6 109/190 THA 11
Enoxaparin 40mg od, 5–9 days 157 65.6 74.9
ODIXA HIP td Rivaroxaban 5,10mg bid, 5–9 days 269 64.5 78 170/231 THA 10
Enoxaparin 40mg od, 5–9 days 132 65 77
Zou Y 2014 Rivaroxaban mg od, 14 days 102 63.5 NR 264/60 TKA 16
Aspirin 100mg od, 14 days 112 65.7
Enoxaparin 40mg od, 14 days 110 62.7
PENTAMAKS Fondaparinux 2.5mg od, 5–9 days 517 67.5 89 427/607 TKA 29
Enoxaprin 30mg bid, 5–9 days 517 67.5 88.4
EPHESUS Fondaparinux 2.5mg od, 5–9 days 1140 66 75 966/1307 THA 32
Enoxaprin 40mg od, 5–9 days 1133 67 75
PENTATHALON Fondaparinux 2.5mg od, 5–9 days 1128 67 81 1078/1179 THA 33
Enoxaprin 30mg bid, 5–9 days 1129 67 80
Fuji T 2008 Fondaparinux 2.5mg od, 11–15 days 165 66.3 56.7 55/277 THA & TKA 31
Placebo 167 66.4 57.6
ALEXANDER G 2001 Fondaparinux 3.0mg od, 5–10 days 177 66 80 203/234 THA 30
Enoxaparin 30mg od, 5–10 days 260 66 81
Fuji T 2014 Edoxaban 30mg od,11–14 days 72 60.6 57.6 18/128 THA 19
Enoxaparin 20mg bid, 11–14 days 74 58.9 56.7
STARS E-3 Edoxaban 30mg od,11–14 days 299 72.6 59.6 120/474 TKA 20
Enoxaparin 20mg bid, 11–14 days 295 72.1 60.7
Fuji T 2010 Edoxaban 30mg od,11–14 days 103 71.4 60.7 47/158 TKA 18
Placebo 102 70.6 61.2
NCT01181167 Edoxaban 30mg od,11–14 days 255 62.8 NR 71/432 THA
Enoxaparin 20mg bid, 11–14 days 248 62.8
EXTEND Ximelagatran 24mg bid, 32–38 days 479 64.7 NR 440/518 THA 26
Enoxaparin 40mg od, 32–38 days 479 63.9
Colwell CW 2003 Ximelagatran 24mg bid, 7–12 days 782 64.5 80.5 749/808 THA 27
Enoxaparin 30mg bid, 7–12 days 775 64 81
EXPRESS Ximelagatran 24mg bid, 8–11 days 1377 67 78 1051/1713 THA & TKA 28
Enoxaparin 40mg od, 8–11 days 1387 67 79.1
Fuji T(E) Enoxaparin 40mg od, 14 days 154 61.8 55.9 43/276 THA & TKA
Placebo 165 65.4 56.6
Hull RD 2000(1) Delteparin 5000IU, od, 8 days 983 63.5 80.5 709/763 THA 35
Warfarin 5-10mg, od, 8 days 489 63 80
Hull RD 2000(2) Delteparin 5000IU, od, 8 days 389 62.5 81 287/282 THA 36
Warfarin 5-10mg, od, 8 days 180 63 81
Anderson DR 2013 Delteparin 5000IU, od, 8–10 days 400 57.9 NR 444/341 THA 34
Aspirin 81mg, od, 8–10 days 385 57.6