Table 3. Univariate and multivariate analyses for PFS and OS.
| Univariate analysis | Multivariate analysis | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value* | HR | 95% CI | P value | |||||||||
| Variables | PFS | OS | PFS | OS | PFS | OS | PFS | OS† | PFS | OS† | PFS | OS† | ||
| Gender | 0.532 | 0.670 | 0.315–0.900 | 0.408–1.098 | 0.019 | 0.112 | 0.722 | - | 0.324–1.611 | - | 0.427 | - | ||
| BMI | 0.968 | 0.960 | 0.931–1.006 | 0.925–0.996 | 0.098 | 0.028 | - | - | - | - | - | 0.269 | ||
| IDH mutation | 0.186 | 0.037 | 0.045–0.770 | 0.001–1.008 | 0.020 | 0.051 | 0.195 | - | 0.039–0.970 | - | 0.046 | - | ||
| Temozolomide average dose | 0.996 | 0.995 | 0.992–0.999 | 0.991–0.999 | 0.020 | 0.018 | 0.999 | - | 0.994–1.004 | - | 0.690 | 0.586 | ||
| Radiotherapy | 0.094 | 0.101 | 0.038–0.228 | 0.050–0.203 | <0.001 | <0.001 | 0.523 | - | 0.062–4.425 | - | 0.552 | 0.456 | ||
| Radiotherapy total dose | 0.995 | 0.972 | 0.971–1.020 | 0.948–0.997 | 0.717 | 0.029 | - | - | - | - | - | - | ||
| Dexamethasone | 2.643 | 2.536 | 1.419–4.922 | 1.336–4.816 | 0.002 | 0.004 | 3.599 | - | 1.197–10.819 | - | 0.023 | 0.231 | ||
| Previous surgery | 1.838 | 2.065 | 1.045–3.231 | 1.192–3.575 | 0.035 | 0.010 | 1.948 | 2.825 | 0.874–4.345 | 1.234–6.466 | 0.103 | 0.014 | ||
| Age at diagnosis | 1.019 | 1.026 | 1.002–1.036 | 1.008–1.045 | 0.029 | 0.006 | 0.987 | - | 0.959–1.016 | - | 0.378 | 0.530 | ||
| EOR | ||||||||||||||
| STR vs biopsy | 0.252 | 0.288 | 0.112–0.567 | 0.146–0.567 | 0.001 | <0.001 | 0.408 | 0.205 | 0.102–1.628 | 0.061–0.697 | 0.204 | 0.011 | ||
| GTR vs biopsy | 0.111 | 0.130 | 0.046–0.267 | 0.061–0.280 | <0.001 | <0.001 | 0.325 | 0.145 | 0.071–1.490 | 0.039–0.539 | 0.148 | 0.004 | ||
| Preoperative | ||||||||||||||
| PNI | 0.922 | 0.566 | 0.522–1.629 | 0.332–0.964 | 0.780 | 0.036 | - | - | - | - | - | 0.369 | ||
| Postoperative | ||||||||||||||
| ECOG | ||||||||||||||
| 1 vs 0 | 1.260 | 1.787 | 0.710–2.235 | 0.961–3.322 | 0.430 | 0.066 | 0.417 | - | 0.179–0.973 | - | 0.043 | 0.115 | ||
| 2 vs 0 | 1.739 | 3.057 | 0.845–3.578 | 1.522–6.141 | 0.133 | 0.002 | 0.645 | - | 0.211–1.975 | - | 0.443 | 0.797 | ||
| 3 vs 0 | 3.795 | 5.471 | 1.597–9.023 | 2.278–13.135 | 0.003 | <0.001 | 0.900 | - | 0.198–4.090 | - | 0.892 | 0.056 | ||
| 4 vs 0 | 0.000 | 9.587 | 0.000–0.000 | 2.079–44.208 | 0.982 | 0.004 | - | - | - | - | - | 0.057 | ||
| Dexamethasone | 1.806 | 2.581 | 1.092–2.985 | 1.525–4.370 | 0.021 | <0.001 | 0.968 | - | 0.477–1.965 | - | 0.928 | 0.140 | ||
| NLR | 1.395 | 1.832 | 0.783–2.484 | 1.054–3.185 | 0.258 | 0.032 | - | - | - | - | - | 0.179 | ||
| PNI | 0.501 | 0.436 | 0.296–0.846 | 0.259–0.735 | 0.010 | 0.002 | 0.804 | - | 0.390–1.659 | - | 0.555 | 0.151 | ||
IDH = isocitrate dehydrogenase, EOR = extent of resection, STR = subtotal resection, GTR = gross total resection, ECOG = Eastern Cooperative Oncology Group, NLR = neutrophil to lymphocyte ratio, PNI = prognostic nutritional index
*P values in bold are significant,
†Results from multivariate analysis with forward selection process Ω.