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. 2021 Jun 17;16(6):e0252518. doi: 10.1371/journal.pone.0252518

Table 1. Bivariate statistics on the complete-case sample (n = 8 113): Allostatic load categories according to confounding and intermediate variables in (A) men and in (B) women.

Allostatic load at 44y
A. Men n(%) n = 4 075 (50%)   B. Women n(%) n = 4 056 (50%)  
Low n(%) Medium n(%) High n(%) P-value* Low n(%) Medium n(%) High n(%) P-value*
  1793 (44.20%) 1386 (34.16%) 878 (21.64%)   1824 (44.97%) 1235 (30.45%) 997 (24.58%)  
Parental interest (7-16y)                
Both interested 930 (51.87%) 634 (45.74%) 348 (39.64%) <0.001 989 (54.22%) 555 (44.94%) 362 (36.31%) <0.001
Low/No interest 698 (38.93%) 578 (41.70%) 427 (48.63%)   654 (35.86%) 524 (42.43%) 488 (48.95%)  
Missing 165 (9.20%) 174 (12.55%) 103 (11.73%)   181 (9.92%) 156 (12.63%) 147 (14.74%)  
Prior confounders              
Parental SEC (birth)                
I & II 405 (22.59%) 240 (17.32%) 103 (11.73%) <0.001 414 (22.70%) 184 (14.90%) 108 (10.83%) <0.001
IIINM 196 (10.93%) 117 (8.44%) 67 (7.63%) 201 (11.02%) 110 (8.91%) 80 (8.02%)  
IIIM 805 (44.90%) 666 (48.05%) 442 (50.34%)   789 (43.26%) 613 (49.64%) 509 (51.05%)
IV&V 295 (16.45%) 262 (18.90%) 211 (24.03%)   309 (16.94%) 248 (20.08%) 240 (24.07%)  
Missing 92 (5.13%) 101 (7.29%) 55 (6.26%)   111 (6.09%) 80 (6.48%) 60 (6.02%)  
Material living conditions (7y)                
Advantaged 1191 (66.42%) 804 (58.01%) 500 (56.95%) <0.001 1158 (63.49%) 735 (59.51%) 570 (57.17%) <0.001
Disadvantaged 337 (18.80%) 360 (25.97%) 241 (27.45%) 399 (21.88%) 308 (24.94%) 300 (30.09%)  
Missing 265 (14.78%) 222 (16.02%) 137 (15.60%)   267 (14.64%) 192 (15.55%) 127 (12.74%)  
Father’s level of education (7y)                
Left school ≥15y 451 (25.15%) 287 (20.71%) 135 (15.38%) <0.001 487 (26.70%) 252 (20.40%) 167 (16.75%) <0.001
Left school <14y 1101 (61.41%) 875 (63.13%) 598 (68.11%)   1067 (58.50%) 795 (64.37%) 677 (67.90%)  
Missing 241 (13.44%) 224 (16.16%) 145 (16.51%)   270 (14.80%) 188 (15.22%) 153 (15.35%)  
Mother’s level of education (birth)                
Left school ≥15y 516 (28.78%) 325 (23.45%) 182 (20.73%) <0.001 552 (30.26%) 300 (24.29%) 173 (17.35%) <0.001
Left school <14y 1189 (66.31%) 971 (70.06%) 640 (72.89%)   1172 (64.25%) 858 (69.47%) 766 (76.83%)  
Missing 88 (4.91%) 90 (6.49%) 56 (6.38%)   100 (5.48%) 77 (6.23%) 58 (5.82%)  
Reading activities (7y)                
Every week 920 (51.31%) 687 (49.57%) 423 (48.18%) 0.263 893 (48.96%) 590 (47.77%) 483 (48.45%) 0.832
Occasionally 488 (27.22%) 355 (25.61%) 240 (27.33%) 548 (30.04%) 389 (31.50%) 304 (30.49%)  
Hardly ever 173 (9.65%) 142 (10.25%) 94 (10.71%)   168 (9.21%) 98 (7.94%) 90 (9.03%)  
Missing 212 (11.82%) 202 (14.57%) 121 (13.78%)   215 (11.79%) 158 (12.79%) 120 (12.04%)  
Outdoor activities (7y)                
Most weeks 1402 (78.19%) 1017 (73.38%) 657 (74.83%) 0.032 1449 (79.44%) 951 (77.00%) 772 (77.43%) 0.41
Occasionally/hardly ever 182 (10.15%) 169 (12.19%) 101 (11.50%) 161 (8.83%) 130 (10.53%) 105 (10.53%)  
Missing 209 (11.66%) 200 (14.43%) 120 (13.67%)   214 (11.73%) 154 (12.47%) 120 (12.04%)  
Place in the sibling (7 y)                
Single child 115 (6.41%) 103 (7.43%) 76 (8.66%) 0.024 119 (6.52%) 107 (8.66%) 79 (7.92%) 0.344
Eldest 511 (28.50%) 347 (25.04%) 210 (23.92%) 481 (26.37%) 317 (25.67%) 273 (27.38%)  
≥ 2 961 (53.60%) 741 (53.46%) 476 (54.21%) 1015 (55.65%) 661 (53.52%) 528 (52.96%)  
Missing 206 (11.49%) 195 (14.07%) 116 (13.21%)   209 (11.46%) 150 (12.15%) 117 (11.74%)  
ACEs (7-16y)                
None 1285 (71.67%) 891 (64.29%) 545 (62.07%) <0.001 1322 (72.48%) 827 (66.96%) 626 (62.79%) <0.001
One or more 399 (22.25%) 374 (26.98%) 259 (29.50%) 389 (21.33%) 320 (25.91%) 298 (29.89%)  
Missing 109 (6.08%) 121 (8.73%) 74 (8.43%) 113 (6.20%) 88 (7.13%) 73 (7.32%)  
Health problems in childhood (7-16y)                
No 1360 (75.85%) 1002 (72.29%) 626 (71.30%) 0.014 1431 (78.45%) 923 (74.74%) 748 (75.03%) 0.090
Yes 416 (23.20%) 376 (27.13%) 248 (28.25%) 383 (21.00%) 302 (24.45%) 244 (24.47%)  
Missing 17 (0.95%) 8 (0.58%) 4 (0.46%) 10 (0.55%) 10 (0.81%) 5 (0.50%)  
Copy-a-Design test (7y)                
Score: med [p25-p75] 8[6–9] 7[6–9] 7[6–8] <0.001 8[6–9] 7[6–8] 7[6–8] <0.001
Missing 183 (10.21%) 180 (12.99%) 110 (12.53%)   188 (10.31%) 131 (10.61%) 109 (10.93%)  
Intermediate life course variables                
Education level (23y)                
A level 468 (26.10%) 270 (19.48%) 117 (13.33%) <0.001 465 (25.49%) 215 (17.41%) 137 (13.74%) <0.001
O level 601 (33.52%) 453 (32.68%) 270 (30.75%) 746 (40.90%) 498 (40.32%) 354 (35.51%)
No level 471 (26.27%) 456 (32.90%) 353 (40.21%)   409 (22.42%) 366 (29.64%) 365 (36.61%)  
Missing 253 (14.11%) 207 (14.94%) 138 (15.72%) 204 (11.18%) 156 (12.63%) 141 (14.14%)  
Malaise inventory (23y)                
No psychological distress 1497 (83.49%) 1134 (81.82%) 705 (80.30%) 0.156 1508 (82.68%) 951 (77.00%) 737 (73.92%) <0.001
Psychological distress 42 (2.34%) 45 (3.25%) 33 (3.76%) 109 (5.98%) 127 (10.28%) 121 (12.14%)
Missing 254 (14.17%) 207 (14.94%) 140 (15.95%)   207 (11.35%) 157 (12.71%) 139 (13.94%)  
Sense of personal control (33y)                
Internal 1387 (77.36%) 1018 (73.45%) 628 (71.53%) 0.012 1440 (78.95%) 960 (77.73%) 740 (74.22%) 0.037
External 132 (7.36%) 114 (8.23%) 78 (8.88%) 187 (10.25%) 129 (10.45%) 135 (13.54%)
Missing 274 (15.28%) 254 (18.33%) 172 (19.59%)   197 (10.80%) 146 (11.82%) 122 (12.24%)  
Occupational social class (33y)                
I & II 713 (39.77%) 460 (33.19%) 245 (27.90%) <0.001 609 (33.39%) 339 (27.45%) 225 (22.57%) <0.001
IIINM 178 (9.93%) 113 (8.15%) 68 (7.74%) 553 (30.32%) 393 (31.82%) 306 (30.69%)  
IIIM 442 (24.65%) 396 (28.57%) 265 (30.18%)   108 (5.92%) 77 (6.23%) 70 (7.02%)  
IV&V 186 (10.37%) 163 (11.76%) 134 (15.26%)   289 (15.84%) 242 (19.60%) 217 (21.77%)  
Missing 274 (15.28%) 254 (18.33%) 166 (18.91%)   265 (14.53%) 184 (14.90%) 179 (17.95%)  
Wealth (33y)                
Owner highest price 370 (20.64%) 203 (14.65%) 87 (9.91%) <0.001 395 (21.66%) 186 (15.06%) 118 (11.84%) <0.001
Owner high price 356 (19.85%) 220 (15.87%) 109 (12.41%)   350 (19.19%) 203 (16.44%) 129 (12.94%)  
Owner median price 293 (16.34%) 232 (16.74%) 141 (16.06%) 329 (18.04%) 234 (18.95%) 156 (15.65%)  
Owner lowest price 281 (15.67%) 224 (16.16%) 169 (19.25%)   281 (15.41%) 200 (16.19%) 182 (18.25%)  
Not owner 273 (15.23%) 293 (21.14%) 231 (26.31%)   274 (15.02%) 270 (21.86%) 299 (29.99%)  
Missing 220 (12.27%) 214 (15.44%) 141 (16.06%)   195 (10.69%) 142 (11.50%) 113 (11.33%)  
Smoking (42y)                
Non-smoker 894 (49.86%) 572 (41.27%) 297 (33.83%) <0.001 885 (48.52%) 530 (42.91%) 398 (39.92%) <0.001
Ex smoker 510 (28.44%) 328 (23.67%) 200 (22.78%) 506 (27.74%) 295 (23.89%) 184 (18.46%)  
Smoker < 10 cig./day 130 (7.25%) 108 (7.79%) 51 (5.81%)   143 (7.84%) 85 (6.88%) 65 (6.52%)  
Smoker 10 to 19 cig./day 90 (5.02%) 116 (8.37%) 99 (11.28%)   134 (7.35%) 166 (13.44%) 118 (11.84%)  
Smoker more than 20 cig./day 116 (6.47%) 203 (14.65%) 200 (22.78%)   106 (5.81%) 129 (10.45%) 193 (19.36%)  
Missing 53 (2.96%) 59 (4.26%) 31 (3.53%)   50 (2.74%) 30 (2.43%) 39 (3.91%)  
Alcohol consumption (42y)              
Moderate 1078 (60.12%) 730 (52.67%) 375 (42.71%) <0.001 1249 (68.48%) 769 (62.27%) 542 (54.36%) <0.001
Abstinent 237 (13.22%) 233 (16.81%) 192 (21.87%) 416 (22.81%) 364 (29.47%) 346 (34.70%)
High 425 (23.70%) 365 (26.33%) 280 (31.89%)   109 (5.98%) 72 (5.83%) 70 (7.02%)  
Missing 53 (2.96%) 58 (4.18%) 31 (3.53%)   50 (2.74%) 30 (2.43%) 39 (3.91%)  
Physical activity (42y)                
Active 1253 (69.88%) 877 (63.28%) 487 (55.47%) <0.001 1252 (68.64%) 793 (64.21%) 557 (55.87%) <0.001
Moderate 168 (9.37%) 122 (8.80%) 90 (10.25%)   124 (6.80%) 103 (8.34%) 71 (7.12%)  
Inactive 318 (17.74%) 329 (23.74%) 270 (30.75%) 398 (21.82%) 308 (24.94%) 330 (33.10%)
Missing 54 (3.01%) 58 (4.18%) 31 (3.53%)   50 (2.74%) 31 (2.51%) 39 (3.91%)