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. 2021 Jun 3;12:655531. doi: 10.3389/fphar.2021.655531

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Copyright © 2021 Ai, Shi, Zuo, Sun, Chen, Wang, Li, Song, Dai, Mu, Ding, Li, Li, Xiao, Zhan and Bai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SolB significantly inhibited hepatocyte injury in vitro (A) The effect of the constituents of Schisandra sphenanthera on APAP-induced hepatocyte injury (B) Cell viability of L02 cells treated with SolB for 24 h were detected (C,D) Survival rate by CCK-8 (C) and the release of LDH (D) of L02 cells treated with SolB and then exposed to APAP (E) Early apoptotic of L02 cells were treated with SolB and then exposed to APAP, and detected by Flow cytometry. Data are expressed as Mean ± SD from three biological replicates (n = 3). Statistics differences were analyzed using One-way ANOVA followed by Dunnett’s test:*p < 0.05, **p < 0.01, ***p < 0.001; NS, no significance.