Table 3.

Estimates from random effects models of associations of time-varying time-varying CRP, adiponectin and systolic and diastolic blood pressure with BMI and body composition, adjusted for covariates¹.

	CRP (mg/L)		8-iso-PGF2α (ng/ml)		Adiponectin (μg/ml)		SBP (mmHg)		DBP (mmHg)
Independent variables	β±SE	P	β±SE	P	β±SE	P	β±SE	P	β±SE	P
BMI	0.27 ± 0.07	<0.001	0.01 ± 0.03	0.75	−5.73 ± 2.87	0.045	0.51 ± 0.07	<0.001	0.38 ± 0.05	<0.001
Weight status2
Underweight	−0.26 ± 2.43	0.92	−0.13 ± 1.63	0.94	−29.03 ± 67.29	0.67	−0.41 ± 2.65	0.88	−0.58 ± 2.47	0.82
Normal weight (ref)	-	-	-	-		-	-	-	-	-
Overweight	0.19 ± 0.53	0.71	−0.26 ± 0.31	0.41	−18.50 ± 18.02	0.31	1.34 ± 0.59	0.02	1.80 ± 0.48	<0.001
Obese	3.91 ± 0.69	<0.001	0.68 ± 0.37	0.06	−46.5 ± 28.39	0.10	4.75 ± 0.75	<0.001	4.13 ± 0.56	<0.001
Total fat mass (kg)	0.07 ± 0.03	0.01	−0.0002 ± 0.02	0.99	−0.67 ± 0.95	0.48	0.03 ± 0.03	0.37	0.03 ± 0.03	0.24
Total lean mass (kg)	0.03 ± 0.06	0.58	0.004 ± 0.03	0.91	−1.83 ± 2.15	0.40	0.32 ± 0.07	<0.001	0.10 ± 0.05	0.06
Percent fat (%)	0.16 ± 0.04	<0.001	0.03 ± 0.02	0.26	−2.41 ± 1.49	0.11	0.17 ± 0.05	0.001	0.10 ± 0.04	0.003
Trunk fat mass (kg)	0.35 ± 0.08	<0.001	0.03 ± 0.05	0.59	−4.67 ± 3.25	0.15	0.42 ± 0.10	<0.001	0.22 ± 0.07	0.003
Trunk lean mass (kg)	0.13 ± 0.12	0.27	−0.007 ± 0.07	0.92	−3.40 ± 4.47	0.45	0.62 ± 0.14	<0.001	0.26 ± 0.11	0.02
Trunk percent fat (%)	0.15 ± 0.04	<0.001	0.03 ± 0.02	0.18	−2.19 ± 1.35	0.11	0.17 ± 0.04	<0.001	0.11 ± 0.03	<0.001

BMI, body mass index; CRP, c-reactive protein; 8-iso-PGF_2α, 8-iso-prostaglandin-F2alpha; SBP, serum blood pressure; DBP, diastolic blood pressure

¹Separate models for each independent variable, adjusted for time, treatment assignment, baseline age, diabetes duration, insulin regimen, sex, and time-varying glycemic control (glycated hemoglobin), height, Tanner stage and physical activity.

²Underweight = BMI percentile < 5; Normal weight = 5 ≤ BMI percentile < 85; Overweight = 85 ≤ BMI percentile < 95; Obese = BMI percentile ≥95