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. 2021 Jun 3;12:625145. doi: 10.3389/fgene.2021.625145

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Copyright © 2021 Wang, Sun, Jin, Fan and Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification and functional enrichment of differentially expressed genes. (A) Heatmap for DEGs generated by comparison of the high ImmuneScore group with the low ImmuneScore group. Rows and columns represent DEGs and samples, respectively. Significant DEGs were determined with FDR < 0.05 and | fold-change| > 1.5 after log2 transformation. (B) Heatmap for DEGs in StromalScore, similar with (A). (C,D) Venn plots showing common upregulated and downregulated DEGs shared by ImmuneScore and StromalScore. (E) GOChord plot of GO enrichment analysis for common DEGs showing enriched GO terms and corresponding genes. The significance level was set to be with both FDR and q < 0.05. (F) Cnetplot of KEGG enrichment analysis for common DEGs showing enriched KEGG terms and corresponding genes. The significance level was set to be with both FDR and q < 0.05.