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. 2021 Jun 18;9:31. doi: 10.1186/s40635-021-00394-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Study flowchart. 400 patients with suspected acute infection and ≥ 1 vital sign (VS) changes from six EDs in Greece were enrolled. Three physicians used electronic health records (EHRs) data alongside results from PCT, CRP, and respiratory syndromic panels to establish ground truths for the presence of bacterial and viral infections. InSep performance was compared to ground truths