Table 1.

Therapeutic application targeting MQC to attenuate IR injury.

Therapies	Mechanisms	References
Dapagliflozin	Improve left ventricular function	Lahnwong et al., 2020 [122]
Melatonin	Improve PPARγ expression	Zhou et al., 2017 [123]
Istaroxime	Stimulate SERCA to dilate blood vessels and decrease ROS production	Hasenfuss et al., 2011 [125]
SS31-Mito	Enhance LVEF and energy integrity with higher PGC-1α and Cyt c	Lee et al., 2018 [127]