Table 3.

Confirmation of the deleterious nsSNPs by other prediction software.

AAS	LRT	Mutation Taster	Mutation Assessor	PROVEAN	FATHMM	VEST3	MetaLR	M-CAP	CADD	DANN	FATHMM-MKK	PhD-SNP	PANTHER	SNP-GO	SNAP2
G330E	D	D	H	D	D	D	D	D	D	D	D	D	D	D	E
C102S	D	D	M	D	D	D	D	D	D	D	D	D	D	D	E
C174R	D	D	H	D	D	D	D	D	D	D	D	D	D	D	E
G107D	D	D	L	D	D	D	D	D	D	D	D	D	D	D	E
R125W	D	D	L	D	D	T	D	D	D	D	D	D	D	N	E
G327R	D	D	H	D	D	D	D	D	D	D	D	N	D	N	E
P290L	D	D	M	D	T	D	D	D	D	D	D	N	D	N	E
K355T	D	D	M	N	D	D	D	D	D	D	D	D	D	N	E
Q353R	D	D	M	N	D	D	D	D	D	D	D	D	D	N	E
D336N	D	D	M	N	D	T	D	D	D	D	D	D	D	N	E
T153N	D	D	M	N	D	T	D	D	D	D	D	D	D	N	E
C75S	D	D	L	D	D	D	D	D	D	T	D	N	D	N	E
P87S	D	D	L	N	D	D	D	D	D	D	D	D	D	N	E
T144M	D	D	L	N	D	D	D	D	D	D	D	N	D	N	E
R118L	D	D	L	D	D	D	T	D	D	D	D	D	D	N	E
D397Y	N	D	M	D	D	T	D	D	D	T	D	D	D	N	E
R301W	D	D	M	D	T	D	T	D	D	D	D	N	D	N	E
P249S	D	D	M	N	T	T	D	D	D	D	D	N	D	N	N
D41E	D	P	L	N	D	T	T	D	D	T	D	D	D	N	N
S19N	N	P	L	N	D	T	D	D	D	D	D	N	D	N	N
R167W	N	D	L	N	D	T	D	D	D	D	D	N	N	N	E
A96G	D	D	L	N	T	D	T	D	D	D	D	N	D	N	N
P181S	N	D	L	N	T	D	T	D	D	T	D	N	N	N	N

D: deleterious; T: tolerated; U: unknown; L: low; N: neutral; M: medium; P: polymorphism; E: effect. Thresholds for all these predication tools are given in the S4 fill.