Figure 4.

NMDA-induced currents in ERβ-expressing PVN neurons in brain slices of AngII-infused VCD-injected female mice. A, Application of NMDA (30 μm) results in a depolarization of ERβ-expressing PVN neurons in AngII-infused VCD-injected females (N = 3; n = 6) that is reduced following application of DPN (10 μm; N = 3; n = 4). B, Representative traces from AngII-infused VCD-injected mice show that DPN reduces the amplitude of NMDA currents. *p < 0.05 (Welch-corrected Student’s t test). Calibration: 400 pA, 3 s. Data are mean ± SEM.