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. 2021 Mar 26;153(2):211–222. doi: 10.1007/s11060-021-03739-1

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© The Author(s) 2021, corrected publication 2021

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Fig. 1 — In vivo optical imaging of 800CW-TATE in H69 and CH-157MN xenografted mice. a Representative images of H69 xenograft bearing mice injected with 800CW-TATE showed accumulation of fluorescence in the tumor after one and two hours, and stabilized four hours post injection (top panel). Imaging of SSTR₂-positive H69 xenograft bearing mice injected with DOTA-TATE and 800CW-TATE (second panel) or IRDye800CW (third panel), and SSTR₂-negative CH-157MN xenograft bearing mice injected with 800CW-TATE (bottom panel) showed reduced accumulation of fluorescence compared with mice injected with 800CW-TATE. b The co-administration of DOTA-TATE as a block slightly reduced 800CW-TATE fluorescence at all timepoints, possibly due to uptake of 800CW-TATE in the skin, thereby distorting the signal. CH-157MN xenografts did not show tracer uptake due to the absence of SSTR₂ expression. IRDye800CW showed a significantly reduced tumor fluorescence in H69 xenografts