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. 2021 Mar 26;153(2):211–222. doi: 10.1007/s11060-021-03739-1

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© The Author(s) 2021, corrected publication 2021

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Fig. 2 — Ex vivo optical imaging of resected tissues from H69 or CH-157MN xenograft bearing mice. a H69 xenografted mice treated with 800CW-TATE were examined for tracer tissue distribution four hours post-injection. Fluorescence uptake was measured with the PEARL and demonstrated uptake mainly in the tumor, skin, kidneys, urine, and liver. In contrast, the fluorescence intensity was (very) low in the brain, skull, muscle, and blood. b The indicated xenografted mice were injected with 800CW-TATE in absence or presence of DOTA-TATE or with non-targeted IRDye800CW. Quantification of fluorescence intensity revealed the indicated biodistribution. c Tissue-to-brain ratios for 800CW-TATE were calculated for the indicated tissues, with a TBR of 21.1. d Tumor fluorescence significantly decreased in the groups co-administrated with DOTA-TATE, the groups administered with IRDye800CW carboxylate, and in CH-157MN xenografts (p < 0.0001). ns, not significant; Δ, difference