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. 2021 Jun 17;12:3684. doi: 10.1038/s41467-021-24010-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a TAMs had enriched expression for multiple immunosuppressive markers. b TAM cell clusters expressing cancer-promoting M2 macrophage marker CD163 had concurrent enrichment for LAIR1 expression. c Expressions of CD163 and LAIR1 were significantly correlated in both in-house and TCGA datasets. Student’s t test (two-sided). d High expressions of LAIR1 and HAVCR2 were significant associated with poorer disease-free and overall survivals, respectively. Log-rank test (two-sided). e Overlap of the LAIR1 and M2 macrophages (CD163) using multicolor immunofluorescence staining in Case #713. Scale bar = 50 µm. More than ten fields each under ×40 and ×100 magnification were examined. Source data are provided as a Source Data file.