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. 2021 Jun 17;4:749. doi: 10.1038/s42003-021-02233-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Appropriate cellular models of the epithelial compartment of the uterus (1) can be established as organoids and progenitor cell cultures, which can be derived from primary patient cells. The stromal compartment (2) can be founded by induced pluripotent stem cells (iPSC) or embryonal stem cells (ESC) cultures, or mesenchymal stem cells (MSC) derived from primary cell culture. The vasculature compartment (3) can be derived from iPSCs, ESCs or directly from primary cells, and immune cells of the endometrium build the immune compartment (4).