FIGURE 2.

Effects of oxaliplatin on the electrophysiological properties of IB4⁺ and IB4^– subpopulations of small DRG neurons. Oxaliplatin (50 μM) was pre-treated in the recording chamber for 15–60 min. The passive and active properties of IB4⁺ and IB4^– subpopulations of small DRG neurons were recorded and presented in the same way described in the legend of Figure 1. Oxaliplatin did not change the Cm of both IB4⁺ and IB4^– neurons (A) but decreased the Rm (B) and depolarized the RMP (C) in IB4^– neurons; (D,E) Representative recordings from IB4⁺ or IB4^– DRG neurons in the absence or presence of oxaliplatin, respectively. (F) The effect of oxaliplatin on rheobase of IB4⁺ and IB4^– neurons. (G,H) The effect of oxaliplatin on the firing frequency of IB4⁺ (G) and IB4^– (H) neurons, respectively. n = 8–14 for each group (see detailed numbers for each group in results). *P < 0.05, **P < 0.01, ***P < 0.001, Student’s t-test (B,C,F) or Two-way repeated measure ANOVA (H).