FIGURE 4.

Effects of selective TRP channel antagonists on the electrophysiological properties of IB4⁺ and IB4^– subpopulations of small DRG neurons. Selective antagonists for TRPA1 (1 μM A-967097), TRPV1 (10 μM Capsazepine, CPZ), or TRPM8 (10 nM TC-I) were pre-treated in the recording chamber for 15 min before the addition of 50 μM oxaliplatin. The passive and active properties of IB4⁺ and IB4^– subpopulations of small DRG neurons were recorded and presented in the same way described in the legend of Figure 1. (A-C) Representative recordings in the absence or presence of oxaliplatin, and in the presence of A-967097, Capsazepine, and TC-I, respectively. Effect of oxaliplatin on Rm (D), RMP (E) and Rb (F) in each group of TRP antagonists. (G) Number of action potentials evoked by 100 pA current injection in each group of cells. n = 6–12 for each group (see detailed numbers for each group in results). *P < 0.05, ***P < 0.001, Student’s t-test.