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. 2021 Jun 17;6:35. doi: 10.1038/s41536-021-00144-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Different sources of hSCs could be (i) differentiated in vitro to the main cutaneous lineages and then, uses to fabricate artificial skin; (ii) embedded directly into dermal scaffolds and engrafted to achieve an in vivo differentiation; or (iii) combined with human keratinocytes and fibroblasts to benefit from their own angiogenic and immunomodulatory properties. hSSCs human skin stem cell, hiPSCs human-induced pluripotent stem cells, hMSCs human mesenchymal stem cells. Created with BioRender.com.