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. 2021 Jun 17;12:3697. doi: 10.1038/s41467-021-23912-4

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Predictions and interquartile ranges from mathematical modeling predictions are shown in a dashed red line and shaded regions, respectively. Observations with two standard errors are shown in black dots and error bars, respectively. The RPC9 (RPC9-CL6) clone is composed of 90% exon 19 del cells 10% exon 19 del and T790M alleles. a PC9-RPC9 cell pool in 10–1 ratio. Our predictions ranked schedules correctly, detecting a difference between the two best schedules at day 30 (p = 0.0159, two-sided t-test with n = 6 biological samples). b PC9-RPC9 cell pool in 100–1 ratio. Our predictions ranked schedules correctly except for the worst 2 schedules, but the difference between the schedules was not statistically significant in the observed data (p = 0.294, two-sided t-test with n = 6 biological samples). Source data are provided as a Source Data file.