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. 2021 Jun 17;12:3709. doi: 10.1038/s41467-021-24110-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a UMAP visualization of dermal skin cell populations of patients with scleroderma (data from NCBI Gene Expression Omnibus (GSE160536)) in the left panel, and a normal scar (NS3) sample from our data is showed on the right. b Integration analysis of two sources of fibroblasts, one from scleroderma, and the other one from a normal scar. c Divided UMAP visualization of the integration results. d Feature plots of the expression distribution of mesenchymal signature genes in scleroderma and normal scar fibroblasts. e Correlation analysis of the average expression level of cluster 7 cells (scleroderma) and four types of fibroblasts from keloid samples. f Immunofluorescence staining of NREP and ADAM12 in normal and scleroderma tissues. Arrowheads indicate NREP⁺/ADAM12⁺ cells. Scale bar = 200 μm. g Percentage of NREP⁺/ADAM12⁺ cells in normal and scleroderma tissues. Data are presented as mean values ± SD (n = 5 images examined over 3 independent experiments). Two-sided unpaired t-test, ***P = 0.00013.