Table 2.

Demographics and proof-of-concept for the primary outcome measure of cerebral blood flow area under the curve.

	Younger (n = 9)	Older (n = 7)
Age, yrs	26 [23–29]	77 [71–81]
Female, %	5 (56%)	6 (86%)
Resting heart rate, bpm	79 [61–95]	62 [54–71]
Resting MAP, mmHg	88 [73–109]	94 [77–112]
Mean workload, Watts	89 [49–128]	30 [0–49]
Peak workload, Watts	96 [60–135]	31 [0–50]
MAP AUC, mmHg*min	2970 [2553–3193]	3646 [3349–3959]
CBF AUC, mL*100 g-1	2742 [1710–3729]	2308 [1926–2688]

Values mean [range] unless otherwise noted. AUC measures are cumulative over the 34:48 min of MRI CBF acquisition.

Bpm beats per minute, mmHg millimeters of mercury, CBF cerebral blood flow, MAP mean arterial pressure, AUC area under curve.