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. 2021 Jun 17;12:3689. doi: 10.1038/s41467-021-23884-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Contrast enhanced mean image of example FOV from Monkey X, site 2, one of 36 analyzed imaging sessions. b Reaching kinematics observed during behavioral task. Move indicates movement onset; Acq indicates target acquisition. c ROI tuning map showing preferred direction of ROIs with significant direction tuning. Inset color wheel indicates reach direction. d Trial-averaged responses of dendritic ROIs, normalized to baseline fluorescence, for the four reaching directions indicated by the colored arrow in the bottom left of each raster. ROIs are sorted by preferred direction beginning with rightwards and proceeding counterclockwise; triangular ticks at left edge indicate locations of preferred directions of up-right, up-left, down-left, down-right. e Single-trial (thin lines) and trial-averaged (thick lines) population trajectories aligned to behaviorally-defined movement onset, projected along condition-independent signal (CIS) dimension and condition-dependent TDR X and Y dimensions (see “Methods” section), color coded by reach direction condition.