Table 1.
Screening visit | Second visit | Annual Follow-up | ||||
---|---|---|---|---|---|---|
Children/adolescentsa | Parentsb | Children/adolescentsc | Parents | Children/adolescentsc | Parents | |
Sociodemographic information | X | X | X | |||
Psychiatric diagnostic | X | X | X | X | ||
Psychometric evaluationd | X | X | Xe | X | X | |
Neuropsychological evaluationf | X | |||||
Saliva sample | X | X | ||||
Blood sample | X | X | ||||
Neuroimagingg | X |
All children and adolescents potentially eligible.
Both parents preferable.
Qualified for the HBR (meets criteria for BD I, II or other specified bipolar and related disorder, offspring of parents with BD and healthy controls).
Includes psychiatric symptoms, functionality, stress life events and quality of life.
Self-reports about their children behavior.
At every 2 years of follow-up.
Scheduled after the two baseline assessments for structural MRI, magnetic resonance spectroscopy (MRS), diffusion tension imaging (DTI), and resting-state functional MRI (fMRI).