Table 1.
Demographic and clinical characteristics of African ALS cohort (n = 105).
| ALS African genetics n = 105 | |
|---|---|
| Age at onset, years, mean (± SD) | 51 (±14) |
| Male, n (%) | 56 (53%) |
| Familial ALS, n (%) | 3 (3%) |
| Region of symptom onset, n (%) | |
| Cognitive | 3 (3%) |
| Bulbar | 20 (19%) |
| Cervical | 37 (35%) |
| Diaphragm | 2 (2%) |
| Lumbosacral | 43 (41%) |
| Phenotype at presentation | |
| Mixed upper motor and lower motor neuron | 85 (81%) |
| Pure upper motor neuron | 11 (10%) |
| Pure lower motor neuron | 7 (7%) |
| ALS-FTD | 2 (2%) |
Familial ALS refers to families in which there are at least 2 biologically related individuals with ALS. FTD -frontotemporal dementia.