The effects of insulin, glibenclamide, Schiff base I, and Schiff base II on behavioral despair in the OAT (a), OAE (b), and locomotor activity (c). Values are expressed as mean ± S.E.M. from 8 rats and were analyzed by one-way ANOVA followed by Tukey’s post hoc test. * p < 0.05 in comparison to the saline group. ++ p < 0.01 and + p < 0.05 in compared with the saline/streptozotocin group