Table 1.
Experiments | Fig. | Drug injection (Intraperitoneally) | Effect on anxiety | Effect on depression | Effect on pain |
---|---|---|---|---|---|
1 | A | Saline 1 ml/kg, Insulin 1 ml/kg, Glibenclamide 5 mg/kg, Schiff base I 50 mg/kg, Schiff base II 25, 50, 100 mg/kg |
Diabetes(anxiogenic) Drugs (anxiolytic) |
- | - |
B | Saline 1 ml/kg, Insulin 1 ml/kg, Glibenclamide 5 mg/kg, Schiff base I 50 mg/kg, Schiff base II 25, 50, 100 mg/kg | No effect | - | - | |
C | Saline 1 ml/kg, Insulin 1 ml/kg, Glibenclamide 5 mg/kg, Schiff base I 50 mg/kg, Schiff base II 25, 50, 100 mg/kg | No effect | - | - | |
2 | A | Saline 1 ml/kg, Insulin 1 ml/kg, Glibenclamide 5 mg/kg, Schiff base II 25, Schiff base II 25 mg/kg + Insulin 1 ml/kg, Schiff base II 25 mg/kg + Glibenclamide 5 mg/kg | No effect | - | - |
B | Saline 1 ml/kg, Insulin 1 ml/kg, Glibenclamide 5 mg/kg, Schiff base II 25, Schiff base II 25 mg/kg + Insulin 1 ml/kg, Schiff base II 25 mg/kg + Glibenclamide 5 mg/kg | Anxiolytic | - | - | |
C | Saline 1 ml/kg, Insulin 1 ml/kg, Glibenclamide 5 mg/kg, Schiff base II 25, Schiff base II 25 mg/kg + Insulin 1 ml/kg, Schiff base II 25 mg/kg + Glibenclamide 5 mg/kg | No effect | - | - | |
3 | A | Saline 1 ml/kg, Insulin 1 ml/kg, Glibenclamide 5 mg/kg, Schiff base I 50 mg/kg, Schiff base II 25, 50, 100 mg/kg | - | Diabetes(depressant) Drugs(antidepressant) | - |
B | Saline 1 ml/kg, Insulin 1 ml/kg, Glibenclamide 5 mg/kg, Schiff base II 25, Schiff base II 25 mg/kg + Insulin 1 ml/kg, Schiff base II 25 mg/kg + Glibenclamide 5 mg/kg | - | No effect | - | |
4 | A | Saline 1 ml/kg, Insulin 1 ml/kg, Glibenclamide 5 mg/kg, Schiff base I 50 mg/kg, Schiff base II 25, 50, 100 mg/kg | - | - | Diabetes(hyperalgesia) Drugs (analgesia) |
B | Saline 1 ml/kg, Insulin 1 ml/kg, Glibenclamide 5 mg/kg, Schiff base II 25, Schiff base II 25 mg/kg + Insulin 1 ml/kg, Schiff base II 25 mg/kg + Glibenclamide 5 mg/kg | - | - | No effect |