Fig. 4.

Effect of phloridzin (PHLO) on immobility time of diabetic mice in forced swim test (a) and tail suspension test (b). While normal pellet diet (NPD) fed control animals received oral saline, different groups of high-fat diet (HFD) + streptozotocin (STZ)-induced type 2 diabetic mice were treated daily with saline, phloridzin (PHLO; 10-20 mg/kg) and fluoxetine (FLU; 10 mg/kg) via oral route for a period of 4 weeks. The data were analyzed by one-way ANOVA followed by Bonferroni’s multiple comparison test. Each bar represents the mean±SEM of each group (n=8 per group). *p<0.001 vs NPD control group; ^#p<0.05, ^##p<0.01, ^###p<0.001 vs HFD-STZ-diabetic group