Table 1.
List of treatment-related mutations acquired in each of the iPI3K-δ resistant tumors sequenced by WES
| Mutations in iPI3K-δ–resistant tumors | |||||
|---|---|---|---|---|---|
| Fourth round I-1 | Fourth round I-2 | Fourth round I-3 | Fourth round I-4 | Third round I-5 | Third round I-6 |
| Lypd8 | Pramel1 | Sned1 | Klhl9 | Grb2 | Cd44 |
| Hrh1 | B230219D22Rik | Ddhd1 | Chpt1 | Baz2b | Slc39a12 |
| Mylk | Gpc5 | Pcdh18 | Dnah10 | Irak1bp1 | Fat1 |
| Ddhd1 | Srfbp1 | Fat3 | Enc1 | Usp17lb | Morc2b |
| Elp3 | Clpx | Gdf10 | Il2 | Mpdz | Myct1 |
| Rps12 | Rps12 | Grb2 | Chrna7 | Prkd1 | |
| Gabra4 | Clca4b | Arhgef10l | Xirp2 | Ccp110 | |
| Gc | Mboat1 | Kdm6a | Klhl29 | ||
| Cyp19a1 | Elp3 | Xirp2 | Osbpl1a | ||
| Epb4.1l3 | Siglec1 | Dock5 | Ptk2 | ||
| Plce1 | Eml5 | Ednra | Amy2b | ||
| Klhl29 | Anks4b | Adcy9 | Clpx | ||
| Fat3 | B4galnt3 | ||||
| Mboat1 | Ccdc106 | ||||
| Crim1 | Itga1 | ||||
| Tubal3 | Tmem132e | ||||
| Anks4b | Tubal3 | ||||
| B4galnt3 | Gc | ||||
| Siglec1 | Hrh1 | ||||
| Itga1 | Plce1 | ||||
| Pcdh18 | Mylk | ||||
| Tshb | Lypd8 | ||||
| Clca4b | Calcoco2 | ||||
| Foxp2 | 4930407I10Rik | ||||
Mutations overlapping between the iPI3K-δ–resistant and -sensitive tumors are not included.