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Estimated Pharmacokinetic Parameters of Axitinib in Ocular Tissues After a Single Bilateral SC Injection of Axitinib Suspension (4 mg/Eye) in Dutch-Belted Rabbits
| Matrix | AUC(0-t) (µg·d/g or µg*d/mL) | C max (µg/g or µg/mL) | T max (day) |
|---|---|---|---|
| RCS | 1,260,000 | 22,000 | 4 |
| Retina | 23,800 | 325 | 61 |
| Vitreous humor | 31.1 | 0.858 | 4 |
NC, not calculable.
