Table 4.
Estimated Pharmacokinetic Parameters of Axitinib in Ocular Tissues After a Single Bilateral SC Injection of Axitinib Suspension (0.03 and 0.1 mg/Eye) in Dutch-Belted Rabbits
| Dose (mg/eye) | Matrix | AUC(0-t) (µg·d/g or µg·d/mL) | C max (µg/g or µg/mL) | T max (day) |
|---|---|---|---|---|
| 0.03 | RCS | 338 | 37.2 | 1 |
| Retina | 17.3 | 4.48 | 1 | |
| Vitreous humor | NC | 0.00401 | 1 | |
| 0.1 | RCS | 2320 | 232 | 1 |
| Retina | 28.1 | 6.26 | 1 | |
| Vitreous humor | NC | 0.00458 | 1 |
AUC(0-t), area under the curve until the last measurable concentration; Cmax, observed maximum concentration; Tmax, time to Cmax; NC, not calculable.